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. 2021 Mar 25;15(10):2702–2714. doi: 10.1002/1878-0261.12942

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© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Characterization of the tissue DNA methylation landscape. (A) Unsupervised hierarchical clustering of the 667 CRC‐specific DNA methylation biomarkers in 187 tissue samples. (B) Principal component analysis of CRC, AA and Normal cohort. (C) Correlation of the methylation pattern between CRC and AA group. The mean methylation level was calculated based on 9921 sequenced biomarkers. The values plotted were generated by dividing PCM of the Normal cohort followed by log₂ transformation.