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. 2021 Oct 2;28(1):124–127. doi: 10.1016/j.jiac.2021.09.016

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© 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Plasma concentration of inflammatory cytokine/chemokine levels in COVID-19 patients who received favipiravir with or without minocycline. Sample size was 6 for the MIN group and 5 for the control group. Horizontal bars represent median values. Statistical significance was only tested between values on admission (acute) and before discharge (convalescent) in the Control group and MIN group. However, for IFN-γ, IL-6, and IL-8, only the MIN group was tested because they were clearly elevated in the convalescent phase in the control group. *Values of P < 0.05 were deemed significant. IFN-γ, interferon-gamma; IL, interleukin; MIN, minocycline; TNF-α, tumor necrosis factor alpha.