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. 2021 Oct 2;144:112276. doi: 10.1016/j.biopha.2021.112276

Table 1.

Summary of antiviral treatment strategies with existing clinical data.

Treatment Mechanism Target Clinical benefit? Mortality decrease?
Remdesivir RNA-dependent RNA polymerase ✓/Mixed
Favipiravir RNA-dependent RNA polymerase X
Lopinavir/Ritonavir Viral protease X
Peginterferon λ-1a General viral replication, cell activity Mixed X

✓ - The drug produced the respective column’s effect. X - The drug failed to produce the respective column’s effect. Mixed - The drug produced negative and positive outcomes or only produced positive outcomes in some trials. * - Clinical trials of this drug either failed to exceed 100 participants or lacked any blinding.