Table 3.
Univariate (left panels) and multivariable (right panels) analysis of TMA inclusion bias
| Total | TMA patients | TMA inclusion | TMA patients | TMA inclusion | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | OR (95% CI) | p | n | % | OR (95% CI) | p | |
| Gender | ||||||||||
| Male | 325 | 68 | 164 | 62 | 0.52 (0.35–0.78) | 0.001 | 164 | 62 | 0.56 (0.36–0.88) | 0.011 |
| Female | 151 | 32 | 100 | 38 | 1 | – | 100 | 38 | 1 | – |
| Age at diagnosis | ||||||||||
| < 65 | 236 | 50 | 137 | 52 | 1.23 (0.86–1.77) | 0.26 | 137 | 52 | Not included | |
| > 65 | 240 | 50 | 127 | 48 | 1 | – | 127 | 48 | ||
| Smoker | ||||||||||
| > 20 pack years | 225 | 47 | 115 | 44 | 0.72 (0.50–1.03) | 0.071 | 115 | 44 | NS | |
| < 20 pack years | 251 | 53 | 149 | 56 | 1 | – | 149 | 56 | ||
| Alcohol consumption | ||||||||||
| Yes | 139 | 29 | 78 | 30 | 0.96 (0.65–1.43) | 0.85 | 78 | 30 | Not included | |
| No | 337 | 71 | 186 | 70 | 1 | – | 186 | 70 | ||
| Primary tumor site | ||||||||||
| Oral cavity | 226 | 47 | 137 | 52 | 1 | – | 137 | 52 | 1 | – |
| Oropharynx | 89 | 19 | 64 | 24 | 1.66 (0.98–2.84) | 0.062 | 64 | 24 | 2.34 (1.21–4.54) | 0.012 |
| Larynx | 105 | 22 | 35 | 13 | 0.33 (0.20–0.53) | < 0.001 | 35 | 13 | 0.68 (0.37–1.24) | 0.21 |
| Hypopharynx | 20 | 4 | 11 | 4 | 0.79 (0.32–1.99) | 0.62 | 11 | 4 | 1.64 (0.58–4.63) | 0.35 |
| Other | 36 | 8 | 17 | 6 | 0.58 (0.29–1.18) | 0.13 | 17 | 6 | 0.93 (0.42–2.03) | 0.85 |
| T class | ||||||||||
| T0-2 | 311 | 65 | 173 | 66 | 1.02 (0.70–1.49) | 0.92 | 173 | 66 | Not included | |
| T3-4 | 165 | 35 | 91 | 34 | 1 | – | 91 | 34 | ||
| N class | ||||||||||
| N0 | 312 | 66 | 157 | 59 | 0.54 (0.37–0.80) | 0.002 | 157 | 59 | NS | |
| N + | 164 | 34 | 107 | 41 | 1 | – | 107 | 41 | ||
| Stage | ||||||||||
| 0–II | 232 | 49 | 118 | 45 | 0.70 (0.48–1.00) | 0.049 | 118 | 45 | NS | |
| III–IV | 244 | 51 | 146 | 55 | 1 | – | 146 | 55 | ||
| Recidive in 5 yrs | ||||||||||
| Yes | 137 | 29 | 84 | 32 | 1.40 (0.93–2.12) | 0.11 | 84 | 32 | Not Included | |
| No | 289 | 61 | 152 | 58 | 1 | – | 152 | 58 | ||
| No curative treatment | 49 | 10 | 28 | 11 | 1.20 (0.65–2.21) | 0.56 | 28 | 11 | ||
| Living at 5 years | ||||||||||
| Yes | 253 | 53 | 131 | 50 | 0.72 (0.48–1.08) | 0.11 | 131 | 50 | Not Included | |
| No, died of HNSCC | 150 | 32 | 90 | 34 | 1 | – | 90 | 34 | ||
| No, died of other cause | 73 | 15 | 43 | 16 | 0.96 (0.54–1.69) | 0.88 | 43 | 16 | ||
| Surgical treatment | ||||||||||
| No surgery | 141 | 30 | 0 | 1 | – | 55 | 21 | 1 | – | |
| Local operation | 282 | 59 | 174 | 66 | 1.88 (1.30–2.73) | 0.001 | 174 | 66 | 1.75 (1.05–2.94) | 0.033 |
| Neck dissection | 173 | 36 | 125 | 47 | 3.10 (2.07–4.63) | < 0.001 | 125 | 47 | 2.30 (1.49–3.56) | < 0,001 |
| Treatment type | ||||||||||
| Surgery only | 172 | 36 | 92 | 35 | 1 | – | 92 | 35 | NS | |
| RT only | 51 | 11 | 20 | 8 | 0.56 (0.30–1.06) | 0.075 | 20 | 8 | ||
| CRT only | 75 | 16 | 30 | 11 | 0.58 (0.33–1.01) | 0.052 | 30 | 11 | ||
| RT + surgery | 46 | 10 | 34 | 13 | 2.46 (1.20–5.08) | 0.015 | 34 | 13 | ||
| CRT + surgery | 116 | 24 | 82 | 31 | 2.10 (1.27–3.46) | 0.004 | 82 | 31 | ||
| no treatment | 15 | 3 | 5 | 2 | 0.44 (0.14–1.33) | 0.14 | 5 | 2 | ||
Results from logistic regression modeling