Table 4.
Prognostic performance of investigated biomarker staining intensities
| Total | 5-yr survival | Survival analysis | ||||
|---|---|---|---|---|---|---|
| n | % | alive, n | % | HR | p | |
| p53 | ||||||
| Absent | 73 | 29 | 34 | 47 | 0.91 (0.62–1.36) | 0.65 |
| wt or high | 176 | 71 | 89 | 51 | 1 | – |
| EGFR | ||||||
| Low-moderate | 190 | 78 | 93 | 49 | 1.27 (0.82–1.97) | 0.29 |
| Strong | 53 | 22 | 26 | 49 | 1 | – |
| CIP2A | ||||||
| Low-moderate | 150 | 66 | 79 | 53 | 1.20 (0.81–1.76) | 0.37 |
| High | 78 | 34 | 30 | 38 | 1 | – |
| Oct4 | ||||||
| Negative | 101 | 39 | 56 | 55 | 0.73 (0.50–1.07) | 0.11 |
| Positive | 160 | 61 | 75 | 47 | 1 | – |
| p16 | ||||||
| Negative | 181 | 81 | 81 | 45 | 0.91 (0.68–1.22) | 0.54 |
| Positive | 43 | 19 | 26 | 60 | 1 | – |
| NDFIP1 | ||||||
| Negative | 137 | 60 | 63 | 46 | 1.18 (0.81–1.73) | 0.40 |
| Positive | 90 | 40 | 46 | 51 | 1 | – |
| cMET | ||||||
| Low | 151 | 66 | 76 | 50 | 0.80 (0.55–1.15) | 0.22 |
| Moderate-high | 79 | 34 | 38 | 48 | 1 | – |
Staining distributions, survival rates, and results of multivariable survival analysis (Cox proportional hazards model controlling for age, T class, nodal status and alcohol use)