Table 3.

Prognostic factors for overall, loco-regional progression-free, distant metastases-free and progression-free survival

Clinicopathological characteristics	Univariate analysis	Schoenfeld test	Multivariate analysis
	p	p	Hazard ratio	95% Confidence interval	p
Overall survival (n = 36 events included into multivariate analysis)		0.108 (global)
Gender (male vs. female)	0.188
Agea (< median vs. ≥ median)	<0.001
Tumor site (parotid gland vs. other)	0.007	0.389	0.301	0.110–0.825	0.020
Histology (low-risk vs. high-risk)	0.001	0.008
T-stage (T1–T2 vs. T3–T4)	<0.001	0.536	5.476	2.297–13.054	<0.001
N-stage (N0 vs. N1–N3)	<0.001	0.659	3.067	1.462–6.431	0.003
Resection margins (R0 vs. other)	0.001	0.229	1.574	0.792–3.132	0.196
Surgery (with neck dissection vs. without neck dissection)	0.603
Adjuvant radiotherapy (yes vs. no)	0.141
Loco-regional progression-free survival (n = 44 events included into multivariate analysis)		0.684 (global)
Gender (male vs. female)	0.194
Agea (< median vs. ≥ median)	<0.001
Tumor site (parotid gland vs. other)	0.001	0.992	0.180	0.065–0.501	0.001
Histology (low-risk vs. high-risk)	0.005	0.607	1.038	0.397–2.712	0.940
T-stage (T1–T2 vs. T3–T4)	<0.001	0.646	5.206	2.383–11.373	<0.001
N-stage (N0 vs. N1–N3)	<0.001	0.637	2.528	1.194–5.352	0.015
Resection margins (R0 vs. other)	0.009	0.094	1.121	0.588–2.134	0.729
Surgery (with neck dissection vs. without neck dissection)	0.431
Adjuvant radiotherapy (yes vs. no)	0.097
Distant metastases-free survival (n = 40 events included into multivariate analysis)		0.190 (global)
Gender (male vs. female)	0.096
Agea (< median vs. ≥ median)	<0.001
Tumor site (parotid gland vs. other)	0.006	0.870	0.313	0.116–0.846	0.022
Histology (low-risk vs. high-risk)	<0.001	0.018
T-stage (T1–T2 vs. T3–T4)	<0.001	0.698	5.053	2.201–11.601	<0.001
N-stage (N0 vs. N1–N3)	<0.001	0.446	3.718	1.773–7.794	0.001
Resection margins (R0 vs. other)	0.001	0.102	1.572	0.814–3.034	0.178
Surgery (with neck dissection vs. without neck dissection)	0.456
Adjuvant radiotherapy (yes vs. no)	0.024	0.414	1.247	0.616–2.524	0.540
Progression-free survival (n = 46 events included into multivariate analysis)		0.741 (global)
Gender (male vs. female)	0.108
Agea (< median vs. ≥ median)	<0.001
Tumor site (parotid gland vs. other)	0.001	0.956	0.193	0.071–0.529	0.001
Histology (low-risk vs. high-risk)	0.002	0.764	1.092	0.421–2.831	0.857
T-stage (T1–T2 vs. T3–T4)	<0.001	0.497	4.583	2.158–9.733	<0.001
N-stage (N0 vs. N1–N3)	<0.001	0.706	2.857	1.348–6.055	0.006
Resection margins (R0 vs. other)	0.007	0.110	1.182	0.629–2.223	0.603
Surgery (with neck dissection vs. without neck dissection)	0.359
Adjuvant radiotherapy (yes vs. no)	0.044	0.380	1.125	0.587–2.160	0.722

^aAge: median 61 years, range 9–93 years; factor was excluded a priori from multivariate analysis as a multi-influenced variable