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. 2021 Jul 8;31(10):1106–1122. doi: 10.1038/s41422-021-00529-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP visualization of Group 1 ILCs from Fig. 2a with re-clustered populations mapped on. Colors indicate cell types. b Expression of the known ILC1-related genes in the different ILC1 sub-clusters is shown in bar graph. c Stage (left panel) and site (right panel) information of ILC1 sub-clusters identified in a, indicated by colors. d Dot plots show top 10 DEGs in the ILC1_a, ILC1_b, ILC1_c, ILC1_d clusters. Colors represent gene expression levels, and size encodes the proportion of gene-expressing cells. e Pie charts show the proportions of ILC1_a, ILC1_b, ILC1_c and ILC1_d in tissues. Colors represent cell clusters described in a. f UMAP visualization of the cells in ILC1_d cluster are further separated into NK and ILC1 subgroup by UMAP analysis (left panel). NK score (GEO: GSE70580) is projected onto UMAP visualization, and colors indicate the expression level of NK-related genes (right panel). g Violin plots show the expression level of IL7R and FGFBP2 in NK and ILC1 subgroups defined in f. h The proportions of cell in different cell cycle statues in ILC1 sub-clusters are shown in bar graph. Colors indicate different cell cycle statuses. i The proportions of ILC1 sub-clusters in each embryonic development stages are shown in bar graph. Colors indicate cell types.