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. 2021 Aug 27;31(10):1061–1071. doi: 10.1038/s41422-021-00557-y

Fig. 7. G protein coupling of MC1R.

Fig. 7

a The interactions between MC1R (medium purple) and α5 helix of Gαs (gold) in the cavity at the cytoplasmic region of MC1R. b The interactions between ICL2 of MC1R and Gαs. ICL2 inserts into the groove formed by αN–β1 hinge, β2–β3 loop, and α5 helix of Gαs. c The interactions between the C-terminus of TM5 and α4 helix, α4–β6 loop and β6 sheet of Gαs. d The interactions between ICL1 of MC1R and Gβ. e Comparison of Gs protein coupling between afamelanotide–MC1R–Gs–Nb35–scFv16 complex and afamelanotide–MC1R–Gs–scFv16 complex. The alignment was based on the receptor. Differences are in the αN helix of Gαs and the interactions between helix 8 of MC1R and Gβ.