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. 2021 Oct 1;11:19572. doi: 10.1038/s41598-021-98883-z

Figure 1.

Figure 1

The top signal associated with the Nicotine Metabolite Ratio in European ancestry females and males was found on chromosome 19 in the region containing CYP2A6. The nicotine metabolite ratio was rank-transformed for analysis. Regional plots, generated using LocusZoom44 (freely available at locuszoom.org), show the top overall SNP in European American (EA) females (rs56113850) (a). The influence of rs56113850 on the Nicotine Metabolite Ratio (NMR) in EA females is shown in (b). The rs56113850 SNP was also the top SNP in EA males (c), and the influence of rs56113850 on the NMR in EA males is shown in d). Linkage disequilibrium patterns in (a) and (c) are based upon the hg19/1000 Genomes November 2014 release European reference population. The plots in (b) and (d) were created using SPSS version 23 (can be purchased from IBM, Armonk, New York, USA). The black horizontal line represents the mean rank-transformed NMR in each group, and the P-value is from the GWAS after adjusting for population substructure and NMR covariates.