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. 2021 Oct 1;12:5764. doi: 10.1038/s41467-021-26091-4

Fig. 5. Cd177-deficiency in Treg cells leads to reduced tumorigenesis.

Fig. 5

a Py8119 tumor growth is significantly reduced in Cd177-KO mice compared to WT, P < 0.0001 in female mice challenged with 5×102 cells per inoculation, n = 10 bilateral tumors. b MC38 tumor growth is significantly reduced in Cd177-KO mice compared to WT, P < 0.0001 in male mice challenged with 5×104 cells per inoculation (n = 6 WT and 7 KO). c MC38 tumor growth is significantly reduced in Treg-specific Cd177-KO (Cd177fl/fl/Foxp3-Cre) male mice compared to control male mice either carrying floxed Cd177 allele (Cd177fl/fl) or Cd177fl/+/Foxp3-Cre. P < 0.0001 in mice challenged with 5×104 cells per inoculation (n = 10 WT and 11 Treg-KO). a–c Numbers in parenthesis equates to the number of mice that developed palpable tumors/total mice inoculated. Data are presented as mean ± SEM. Two-way ANOVA was used for a–c.