Skip to main content
. 2021 Oct 1;11:19536. doi: 10.1038/s41598-021-97768-5

Figure 3.

Figure 3

IgLONs mRNA expression in the developing olfactory bulb (OB). In situ hybridization of coronal sections of OB from embryonic day (E) 16 and postnatal day (P) 0 and 15 mice with antisense cRNA probes for IgLON transcripts. IgLON1 mRNA is detected in the mitral cell layer (MCL) of the OB at E16 and is maintained at P0 and P15 (A–C). IgLON2 mRNA expression is observed in the MCL and in the granule cell layer (GCL) of the OB at E16, P0, and P15 (D–F). By P15, IgLON2 expression is also detected in the glomerular cell layer (GL) (F). IgLON3 is expressed in the MCL at E16, P0, and P15, and could also be detected in the GCL at P0 (G–I). IgLON4 mRNA expression is observed at low levels in the GCL and in the MCL at E16 (J). Its expression in these regions is increased at P0 but is downregulated in the MCL at P15 (K, L). IgLON5 mRNA is detected in the MCL and GCL at E16 (E) and P0 (N) and at lower levels at P15 (O). Scale bars = 200 µm (A, B, D, E, G, H, J, K, M, N) and 500 µm (C, F, I, L, O).