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. 2021 Oct 1;12:5756. doi: 10.1038/s41467-021-25875-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Results from two sets of simulations (at least 800 runs for each condition) are compared; one set as Fig. 1, in the other beads around TU beads 905, 907, 930, and 931 (from bead 901 to 940) are non-binding (to represent embedding the TU beads in heterochromatin). A Snapshot with heterochromatic beads shown in gray (TFs not shown; inset—the same structure with only TUs). B Average transcriptional activity for each TU. C Comparison of average transcriptional activity with respect to wild type for the 22 TUs with significantly different values in the two sets (p ≃ 0.003; two-sided Student’s t-test). D Regulatory network inferred from the matrix of Pearson correlations between activities of TUs (as Fig. 3A). E Change in Pearson correlation between TUs due to heterochromatin.