Figure 1.

An overview of what is being done in this study; (A) Timelines of each all the applied treatment methods including classical chemotherapy, thermochemotherapy, ThermoDox therapy, ablation + thermochemotherapy, and ablation + ThermoDox therapy. In all methods, Dox is used as an anti-cancer therapeutic agent (adapted with permission from²⁹). (B) Schematic of MR-HIFU which is used for hyperthermia and ablation. This is an advanced technology that allows the user to make the right decision by monitoring what is happening. (C) Schematic of interactions of therapeutic agents. Drug molecules can mainly bind to proteins in plasma which make them unable to reach their potential. It is assumed that only free drug enters the cell, on the other hand, the cell can expel them due to its multidrug resistant (MDR) properties. (D) Multi-compartment model of the present study. The current mathematical model is based on multi-compartment models that consider each biophysical environment as a compartment, and therapeutic agents are exchanged between these compartments. $S_{\mathit{IO}}$: Exchange of therapeutic agents between systemic circulation and capillary network, $F_{\mathit{IO}}$: Exchange of therapeutic agents between capillary network and interstitium,$E_{\mathit{IO}}$: Exchange of therapeutic agents between interstitium and cell,$k_a$: Association with protein, $k_d$: Dissociation with protein, $\epsilon$: Cellular efflux functions, $\xi$: Cellular uptake functions.