TABLE 4.
Predictors of willingness to use a specific medication modeled after ROSE-010 for acute IBS pain (N=461).
| Variable | Not, rarely, or sometimes willing to use ROSE-010 (n=259) | Most of the time or always willing to use ROSE-010 (n=202) | OR [95% CI] |
|---|---|---|---|
| IBS subtype: | |||
| IBS-C | 70 (27.0) | 43 (21.3) | Ref |
| IBS-D | 77 (29.7) | 49 (24.3) | 1.02 [0.56-1.85] |
| IBS-M | 111 (42.9) | 110 (54.5) | 1.54 [0.90-2.61] |
| IBS-U | 1 (0.4) | 0 (0.0) | --- † |
| Number of acute pain episodes in past month: | |||
| 2 episodes | 58 (22.4) | 31 (15.4) | Ref |
| 3 episodes | 73 (28.2) | 56 (27.7) | 1.10 [0.59-2.07] |
| ≥4 episodes | 128 (49.4) | 115 (56.9) | 1.00 [0.56-1.81] |
| Average severity of acute pain episodes in past month (0-10 scale) | 6.8 ± 1.5 | 7.4 ± 1.4 | 1.12 [0.94-1.32] |
| PROMIS abdominal pain score (percentile; higher=more severe) | 74.8 ± 17.6 | 83.3 ± 14.9 | 1.03 [1.01-1.04] |
| Currently taking IBS medicine | 180 (69.5) | 163 (80.7) | 1.24 [0.74-2.08] |
| Currently taking other medicine for pain | 243 (93.8) | 190 (94.1) | 0.92 [0.38-2.23] |
| Age: | |||
| 18-29 yo | 57 (22.0) | 27 (13.4) | Ref |
| 30-39 yo | 74 (28.6) | 73 (36.1) | 2.36 [1.25-4.47] |
| 40-49 yo | 64 (24.7) | 57 (28.2) | 2.22 [1.15-4.30] |
| ≥50 yo | 64 (24.7) | 45 (22.3) | 2.37 [1.13-4.96] |
| Sex: | |||
| Male | 68 (26.3) | 78 (38.6) | Ref |
| Female | 190 (73.4) | 124 (61.4) | 0.74 [0.46-1.20] |
| Prefer not to say | 1 (0.4) | 0 (0.0) | --- † |
| Race/ethnicity: | |||
| Non-Hispanic White | 202 (78.0) | 138 (68.3) | Ref |
| Non-Hispanic Black | 22 (8.5) | 16 (7.9) | 0.81 [0.37-1.80] |
| Latino | 19 (7.3) | 37 (18.3) | 2.58 [1.30-5.11] |
| Non-Hispanic Asian | 8 (3.1) | 3 (1.5) | 0.59 [0.13-2.62] |
| Other | 8 (3.1) | 8 (4.0) | 1.36 [0.44-4.21] |
| Educational attainment: | |||
| High school degree or less | 52 (20.1) | 48 (23.8) | Ref |
| Some college education | 71 (27.4) | 49 (24.3) | 0.74 [0.40-1.38] |
| College degree | 111 (42.9) | 84 (41.6) | 0.53 [0.29-0.96] |
| Graduate degree | 25 (9.7) | 21 (10.4) | 0.52 [0.22-1.25] |
| Marital status: | |||
| Married | 121 (46.7) | 111 (55.0) | Ref |
| Not married | 138 (53.3) | 91 (45.1) | 0.78 [0.50-1.21] |
| Total household income, $: | |||
| <50,000 | 116 (44.8) | 71 (35.2) | Ref |
| 50,000-100,000 | 91 (35.1) | 92 (45.5) | 1.31 [0.78-2.18] |
| ≥100,001 | 43 (16.6) | 36 (17.8) | 1.07 [0.53-2.17] |
| Prefer not to say | 9 (3.5) | 3 (1.5) | 0.96 [0.23-4.06] |
| Employed or student | 154 (59.5) | 146 (72.3) | 1.98 [1.15-3.40] |
| Has health insurance | 232 (89.6) | 186 (92.1) | 1.82 [0.86-3.86] |
| Has condition that affects GI tract | 168 (64.9) | 162 (80.2) | 2.07 [1.28-3.37] |
| U.S. region: | |||
| Northeast | 46 (17.8) | 25 (12.4) | Ref |
| South | 107 (41.3) | 99 (49.0) | 1.52 [0.79-2.90] |
| Midwest | 66 (25.5) | 45 (22.3) | 1.23 [0.60-2.53] |
| West | 40 (15.4) | 33 (16.3) | 1.41 [0.66-3.03] |
Note: Data are presented as n (%) or mean ± standard deviation. The logistic regression model adjusted for all covariates in the table.
CI, confidence interval; GI, gastrointestinal; IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome with constipation; IBS-D, irritable bowel syndrome with diarrhea; IBS-M, mixed irritable bowel syndrome; IBS-U, unsubtyped irritable bowel syndrome; PROMIS, Patient-Reported Outcomes Measurement Information System; OR, odds ratio; Ref, reference.
†
Those with IBS-U (n=1) and unknown sex (n=1) were not included in the regression model as they perfectly predicted the outcome.