Table 3.
Levels of high sensitivity troponin T (hsTropT) and N-terminal pro-B natriuretic peptide (NTproBNP) among 40 patients who underwent chimeric antigen receptor (CAR) T cell therapy. a b c represent the lower quartile a, the median b, and the upper quartile c. (A and B) Levels of hsTropT and NTproBNP at baseline (BL), day 1, days 7 and 21. (C and D) Levels of hsTropT and NTproBNP stratified by whether patients experienced grade 2 cytokine release syndrome or not (E) Levels of hsTropT stratified by whether it was abnormal (>14 ng/L) at baseline or not. (F) Levels of NTproBNP stratified by whether it was abnormal (>125 pg/mL) at baseline or not
hsTropT levels: Overall | NTproBNP levels: Overall | ||||
|
|
||||
Day | Full group (n = 40) | Day | Full group (n = 40) | ||
| |||||
BL | 9.212.120.1 | BL | 116.0179.1324.8 | ||
1 | 9.613.124.2 | 1 | 97.8357.2813.4 | ||
7 | 9.611.918.0 | 7 | 238.6420.01241.5 | ||
21 | 10.815.320.2 | 21 | 79.7176.8278.4 | ||
| |||||
hsTropT levels: by grade 2 CRS vs. not | NTproBNP levels: by grade 2 CRS vs. not | ||||
|
|
||||
Day | No CRS (n = 22) | Yes CRS (n = 18) | Day | No CRS (n = 22) | Yes CRS (n = 18) |
| |||||
BL | 8.913.121.3 | 9.211.318.0 | BL | 136.4213.9427.6 | 91.5178.9291.3 |
1 | 9.912.625.0 | 9.513.519.6 | 1 | 169.6368.2710.8 | 78.0344.41293.5 |
7 | 10.513.017.6 | 9.311.419.1 | 7 | 166.0373.6711.5 | 393.7949.31381.8 |
21 | 10.215.320.8 | 11.315.319.2 | 21 | 77.5146.4212.7 | 150.9206.6334.5 |
| |||||
hsTropT levels: by abnormal vs. normal baseline hsTropT | NTproBNP levels: by abnormal vs. normal baseline NTproBNP | ||||
|
|
||||
Day | Normal baseline hsTropT (n = 20) | Abnormal baseline hsTropT (n = 17) | Day | Normal baseline hsTropT (n = 20) | Abnormal baseline hsTropT (n = 17) |
| |||||
BL | 7.39.310.2 | 16.721.025.2 | BL | 48.184.5102.1 | 179.0276.4485.1 |
1 | 8.710.011.5 | 16.425.032.7 | 1 | 55.274.8113.8 | 322.9679.01340.0 |
7 | 8.810.411.6 | 13.817.824.0 | 7 | 109.6260.7410.8 | 383.9949.22164.0 |
21 | 9.110.813.6 | 16.920.823.6 | 21 | 52.1120.3158.2 | 138.1210.9424.6 |