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. 2021 Oct 2;564:33–38. doi: 10.1016/j.virol.2021.09.009

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Site specific binding mode of NHC to coronavirus polymerase-RNA complex. The active form of molnupiravir (β-D-N⁴-hydroxycytidine triphosphate; NHC), binding to the RdRp-RNA complex (atom color ribbons) of SARS-CoV-2 (A), HCoV-NL63 (B), HCoV-229E (C) and HCoV-OC43 (D), is depicted as surface representation. H-bond donor (purple) and acceptor (green) interactions are depicted. (E) Summary of binding mode and affinity index (B.E.). HCoV: human coronavirus. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)