Table 1.

Activity of genes in the aging process.

Activity levels during aging young → aged	Compounds with altering in the Boolean network ensembles	Biological impact of altered activity	References
	BIRC3, IRAK4	Loss of rescue mechanisms for apoptosis causing impaired survival	[68], [69]
	CARD14, IKBKB, CYLD	Loss of quiescence	[70], [71], [72], [73], [74], [75], [76]
	TRAF5, LAT	Myeloid skewing	[77], [78], [79], [80]
	MALT1	Compensatory inhibition of NF-$\kappa$B activation via induction of quiescence. Loss of NF-$\kappa$B direct inhibition	[62], [61]
	NFKBIA	Propensity to increased inflammatory response via NF-$\kappa$B activation	[81]
	LYN	Impaired repopulation potential	[82], [83]
	ERC1	Cellular polarity alteration causing reduced motility. Presence of ERC1 promotes the turnover of focal adhesions	[84], [85], [86], [87], [88]
	TNFRSSF13C	Impaired lymphoid specification	[89], [90]
	TNFSF13B	Stable immune response	[63], [64]
	CSNK2A1	Resistance to senescence	[65]
	PIDD1	Control of balance between repair and apoptosis after DNA-damage	[66], [91]
	TNFSF14	Loss of quiescence due to increased cycling	[92]