Table 2.
Pediatric tumors classified by alteration frequencies, classical translocations and deletions, in comparison with adult NSLC
| Tumor type | Alterations/Mb | Classical alterations |
|---|---|---|
| ATRT/MRT✧ | ∼3/whole exome <1 per Mb exome (Grobner et al., 2018) |
del(22q11.23) SNF5/SMARCB1 |
| Myeloid leukemias✧ | <1 per Mb exome 0.6 per Mb exome (Grobner et al., 2018) |
t(11q23) MLL-rearr. t(8; 21) AML-ETO inv(16) CBFb-MYH11 |
| Ewing sarcoma✧ | <1 per Mb exome 0.6 per Mb exome (Grobner et al., 2018) |
(11; 22) (q24; q12) EWS-FLI-1 |
| Diffuse Intrinsic Pontine Glioma✧ | 1.2 per Mb exome (Grobner et al., 2018) | H3.3K27M H3.1K27M |
| Synovial sarcoma✧ | 1.7 per Mb exome (Chalmers et al., 2017) | t(X; 18) SS18-SSX |
| Rhabdomyosarcoma✧ | 1.7 per Mb exome∗ (alveolar) 2.5 per Mb exome (Chalmers et al., 2017) (embryonal) 1.3 per Mb exome (Grobner et al., 2018) (embryonal) |
t(2; 13) (q35; q14) PAX3-FOXO1 |
| MPNST✧ | 2.5 per Mb exome (Chalmers et al., 2017) | del(17q11) NF1▵; SUZ12▵ del(11q14) EED▵ |
| NSCLC▵ | 8.1 per Mb exome (Chalmers et al., 2017) |
SMARCA4 mutations 19p13.2 |
| Osteosarcoma✧ | 14.6 per Mb exome (CNV) (Poos et al., 2015; Kovac et al., 2015) 1.8 per Mb exome (SNV) 1.3 per Mb exome (SNV) (Grobner et al., 2018) |
Complex karyotype/hyperdiploidy −10, -19 +4q, +8q, +17p |
The class of (✧) pediatric tumor and (▵) adult tumor are defined, as well as classical alterations, mutational burden per exome, and relevant pioneer factor.