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. 2021 Oct 2;21:381. doi: 10.1186/s12883-021-02407-1

Table 2.

Common KEGG pathways in different cell types of AD brain

Pathways Cell types
Estrogen signaling pathway Mic, Astro, Oligo, Neuron (In), Endo
MAPK signaling pathway Mic, Astro, Neuron (Ex), Endo
Ribosome Mic, Oligo, Neuron (Ex)
Glutamatergic synapse Astro, Oligo, Neuron (Ex)
Axon guidance Astro, Oligo, Endo
Oxidative phosphorylation Oligo, Neuron (Ex), Neuron (In)
Long-term potentiation Oligo, Neuron (Ex), Neuron (In)
Alzheimer's disease Oligo, Neuron (Ex), Neuron (In)
Parkinson's disease Oligo, Neuron (Ex), Neuron (In)
Huntington's disease Oligo, Neuron (Ex), Neuron (In)
Phagosome Mic, Astro
HIF-1 signaling pathway Mic, Endo
PI3K-Akt signaling pathway Mic, Endo
Antigen processing and presentation Mic, Endo
Mineral absorption Astro, Endo
cAMP signaling pathway Oligo, Neuron (In)
Protein processing in ER Astro, Oligo
Gap junction Astro, Neuron (Ex)
Rap1 signaling pathway Neuron (In), Endo

Mic: Microglia; Astro: Astrocytes; Oligo: Oligodendrocytes; Neuron (Ex): Excitatory neurons; Neuron (In): Inhibitory neurons; Endo: Endothelial cells