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. 2021 Sep 30;11(9):e047670. doi: 10.1136/bmjopen-2020-047670

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Schematic illustration of MLR-DBS. (A) After incomplete SCI, spared fibres of the reticulospinal tract are not sufficient to properly convey motor signals to sublesional locomotor circuits (CPG). The CPGs are thus deprived of their central input. However, these local rhythm generators remain intact. (B) MLR-DBS can recruit spared fibres of the reticulospinal tract system, enabling them to reactivate sublesional motor circuits. (C) Summary. CPG, central pattern generators; DBS, deep brain stimulation; MLR, mesencephalic locomotor region; NRG, gigantocellular reticular nucleus; SCI, spinal cord injury. (A) and (B) were modified from Hofer and Schwab³ with permission.