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. 2021 Sep 30;9(9):e002569. doi: 10.1136/jitc-2021-002569

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Batf3-dependent CD103⁺ dendritic cells play an important role in the anti-tumor effects of IT live OV-GM and heat-iOV-GM. (A) Tumor implantation and treatment plan in a unilateral B16-F10 intradermal implantation tumor model. (B) Tumor volumes of injected tumors in WT mice treated with either live OV-GM (n=23), heat-iOV-GM (n=25), or PBS control (n=7), or Batf3^-/- mice treated with live OV-GM (n=9) or heat-iOV-GM (n=9) over days post-treatment. (C) Kaplan-Meier survival curve of WT and Batf3^-/- mice treated with PBS, live OV-GM, or heat-iOV-GM. (*P < 0.05; ***P < 0.001; ****P < 0.0001). (D) The number of tumor foci on the surface of lungs collected at 3 weeks from either naïve (n=9), or heat-iOV-GM-treated (n=13), or live OV-GM-treated mice (n=14), after intravenous delivery of 1 x 10⁵ B16-F10 cells (*P < 0.05; ****P < 0.0001, t test).