Table 2.
In vitro Activities of Imipenem-Sulbactam, Ampicillin-Sulbactam and Cefoperazone-Sulbactam Against A. baumannii
| Drugs | MIC (mg/L)a | Susceptible Rate (%) | Intermediate Rate (%) | Resistant Rate (%) | ||
|---|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||||
| SUL | 0.5–256 | 32 | 64 | / | / | / |
| IPM | 0.12–128 | 32 | 64 | 13.7 | 1.0 | 85.3 |
| IPM-SUL 2:1 | 0.12–256 | 32 | 64 | 13.7 | 1.0 | 85.3 |
| IPM-SUL 1:1 | 0.12–64 | 16 | 32 | 14.3 | 1.0 | 84.7 |
| IPM-SUL 1:1.5 | 0.12–64 | 16 | 32 | 14.3 | 1.3 | 84.3 |
| IPM-SUL 1:2 | 0.12–64 | 8 | 16 | 15.0 | 3.7 | 81.3 |
| IPM-SUL 1:2.5 | 0.12–64 | 8 | 16 | 15.7 | 9.0 | 75.3 |
| IPM-SUL 1:3 | 0.12–32 | 8 | 16 | 16.3 | 18.3 | 65.3 |
| AMP | 8–>256 | >256 | >256 | 1.3 | 6.3 | 92.3 |
| AMP-SUL 2:1 | 1–>256 | 64 | 128 | 12.3 | 2.0 | 85.7 |
| AMP-SUL 1:1 | 0.5–256 | 32 | 64 | 14.3 | 16.3 | 69.3 |
| AMP-SUL 1:1.5 | 0.25–256 | 16 | 64 | 20.3 | 35.0 | 44.7 |
| AMP-SUL 1:2 | 0.25–256 | 16 | 32 | 28.3 | 46.0 | 25.7 |
| AMP-SUL 1:2.5 | 0.12–128 | 8 | 32 | 51.3 | 35.3 | 13.3 |
| AMP-SUL 1:3 | 0.25–128 | 8 | 16 | 58.3 | 32.7 | 9.0 |
| CFP | 16–>256 | >256 | >256 | 2.3 | 4.7 | 93.0 |
| CFP-SUL 2:1 | 1–>256 | 64 | 128 | 15.0 | 12.7 | 72.3 |
| CFP-SUL 1:1 | 0.5–>256 | 32 | 64 | 29.3 | 47.3 | 23.3 |
| CFP-SUL 1:1.5 | 0.5–256 | 16 | 32 | 66.3 | 24.0 | 9.7 |
| CFP-SUL 1:2 | 0.25–256 | 16 | 32 | 78.7 | 14.0 | 7.3 |
| CFP-SUL 1:2.5 | 0.25–256 | 16 | 32 | 86.3 | 8.0 | 5.7 |
| CFP-SUL 1:3 | 0.25–128 | 8 | 16 | 91.0 | 4.3 | 4.7 |
Notes: aFor MIC of IPM-SUL, AMP-SUL and CFP-SUL combinations, only the concentrations of imipenem, ampicillin and cefoperazone are listed respectively.
Abbreviations: SUL, sulbactam; IPM, imipenem; IPM-SUL, imipenem-sulbactam; AMP, ampicillin; AMP-SUL, ampicillin-sulbactam; CFP, cefoperazone; CFP-SUL, cefoperazone-sulbactam.