Table 3.
In vitro Activities of Ampicillin-Sulbactam and Cefoperazone-Sulbactam Against Carbapenem-Susceptible A. baumannii and Carbapenem-Resistant A. baumannii
| Drugs | MIC (mg/L) | Susceptible Rate (%) | Drugs | MIC (mg/L) | Susceptible Rate (%) | ||
|---|---|---|---|---|---|---|---|
| MIC50 | MIC90 | MIC50 | MIC90 | ||||
| CSAB (n=37) | CRAB (n=263) | ||||||
| SUL | 1 | 2 | / | SUL | 32 | 64 | / |
| AMP | 16 | 32 | 10.8 | AMP | >256 | >256 | 0.0 |
| AMP-SUL 2:1 | 2 | 4 | 100.0 | AMP-SUL 2:1 | 64 | 128 | 0.0 |
| AMP-SUL 1:1 | 1 | 2 | 100.0 | AMP-SUL 1:1 | 32 | 64 | 2.3 |
| AMP-SUL 1:1.5 | 0.5 | 1 | 100.0 | AMP-SUL 1:1.5 | 32 | 64 | 9.1 |
| AMP-SUL 1:2 | 0.5 | 1 | 100.0 | AMP-SUL 1:2 | 16 | 32 | 18.3 |
| AMP-SUL 1:2.5 | 0.5 | 0.5 | 100.0 | AMP-SUL 1:2.5 | 16 | 32 | 44.5 |
| AMP-SUL 1:3 | 0.25 | 0.5 | 100.0 | AMP-SUL 1:3 | 8 | 32 | 52.5 |
| CFP | 32 | 128 | 18.9 | CFP | >256 | >256 | 0.0 |
| CFP-SUL 2:1 | 2 | 4 | 100.0 | CFP-SUL 2:1 | 64 | 128 | 3.0 |
| CFP-SUL 1:1 | 1 | 2 | 100.0 | CFP-SUL 1:1 | 32 | 64 | 19.4 |
| CFP-SUL 1:1.5 | 1 | 1 | 100.0 | CFP-SUL 1:1.5 | 16 | 64 | 61.6 |
| CFP-SUL 1:2 | 0.5 | 1 | 100.0 | CFP-SUL 1:2 | 16 | 32 | 75.7 |
| CFP-SUL 1:2.5 | 0.5 | 1 | 100.0 | CFP-SUL 1:2.5 | 16 | 32 | 84.4 |
| CFP-SUL 1:3 | 0.5 | 0.5 | 100.0 | CFP-SUL 1:3 | 8 | 32 | 89.7 |
Abbreviations: SUL, sulbactam; IPM, imipenem; IPM-SUL, imipenem-sulbactam; AMP, ampicillin; AMP-SUL, ampicillin-sulbactam; CFP, cefoperazone; CFP-SUL, cefoperazone-sulbactam; CSAB, carbapenem-susceptible A. baumannii; CRAB, carbapenem-resistant A. baumannii.