Table 6.
The Mutations in pncA Detected in the PZA Resistance MDR Strains
| PZA Susceptibility | pncA Mutation | Codon | Amino Acid Change | |
|---|---|---|---|---|
| S | R | |||
| 0 | 2 | 22G→A | GAC8AAC | D8N |
| 0 | 1 | 29A→C | CAG10CCG | Q10P |
| 0 | 1 | 42C→A | TGC14TGA | C14end |
| 0 | 1 | 137C→A | GCA46GAA | A46E |
| 0 | 1 | 137C→T | GCA46GTA | A46V |
| 0 | 1 | 152A→C | CAC51CCC | H51P |
| 0 | 3 | 202T→C | TGG68CGG | W68R |
| 0 | 1 | 231Ins | 231Insert | Frameshift |
| 0 | 1 | 246A→C | CAT82CCT | H82P |
| 0 | 4 | 311G→T | AGC104ATC | S104I |
| 0 | 1 | 347T→C | CTG116CCG | L116P |
| 0 | 2 | 389Ins | 389Insert | Frameshift |
| 0 | 1 | 403A→C | ACC135CCC | T135P |
| 0 | 2 | 421C→T | CAG141TAG | Q141end |
| 0 | 1 | 422A→C | CAG141CCG | Q141P |
| 0 | 1 | 478A→G | ACA160GCA | T160A |
| 0 | 1 | 490T→C | TCG164CCG | S164P |
| 0 | 1 | 523A→G | ATG175GTG | M175V |
| 0 | 1 | 278T→G, 319G→A, 376G→A, 422A→C, 541G→A | TCG93TCA, GAG112AAG, CAG141CCG, GAT126AAT, GAG181AAG | V93G, E112K, Q141P, D126N, E181K |
| 1 | 0 | 136G→A | GCA46ACA | A46T |
| 2 | 0 | 345A→C | CCA115CCC | Synonymous mutation |
| 1 | 0 | 383T→G | GTC128GGC | V128G |
| 1 | 0 | 396T→C | GGT132GGC | Synonymous mutation |
| 1 | 0 | 398T→C | ATT133ACT | I133T |
| 1 | 1 | 464T→G | GTG155GGG | V155G |
Abbreviations: PZA, pyrazinamide; S, susceptible; R, resistance.