Table 3.

Univariate and Multivariate Analyses of Risk Factors with and OS in BRCA Patients

Variables	HR (95%CI)	P-value
Univariate analyses
Age (years) (>60 vs ≤60)	2.015 (1.460–2.781)	<0.001
Gender (female vs male)	1.228 (0.171–8.794)	0.838
T stage (T3 and T4 vs T1 and T2)	1.760 (1.223–2.535)	0.002
N stage (N2 and N3 vs N0 and N1)	2.299 (1.571–3.359)	<0.001
M stage (M1 vs M0)	4.859 (2.900–8.139)	<0.001
AJCC tumor stage (III and IV vs I and II)	1.624 (1.373–1.921)	<0.001
AKR1C1 (high group vs low group)	0.640 (0.440–0.931)	0.020
Multivariate analyses
Age (years) (>60 vs ≤60)	2.276 (1.613–3.212)	<0.001
T stage (T3 and T4 vs T1 and T2)	0.985 (0.581–1.668)	0.954
N stage (N2 and N3 vs N0 and N1)	1.075 (0.591–1.955)	0.812
AJCC tumor stage (III and IV vs I and II)	1.654 (1.195–2.290)	0.002
AKR1C1 (high group vs low group)	0.652 (0.440–0.964)	0.032

Abbreviations: HR, hazard ratio; CI, confidence interval; OS, overall survival; AJCC, American Joint Committee on Cancer.