Comparison 2. Nebuliser vs pMDI: secondary outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in peak FEV1 [%]	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Change in FEV1 (ml) closest to 1 h after dosing	4		Mean Difference (Random, 95% CI)	82.98 [10.30, 155.67]
3 Change in dyspnoea score in the first 24 h after dosing	2		Mean Difference (Fixed, 95% CI)	0.12 [‐0.56, 0.79]
4 Change in quality of life on the first day of dosing	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Admission rates	1	22	Odds Ratio (M‐H, Random, 95% CI)	0.8 [0.09, 7.00]
6 Time in hospital emergency department	0	0	Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Length of hospital stay	1	34	Mean Difference (IV, Fixed, 95% CI)	0.80 [‐1.05, 2.65]
8 Change in oxygen saturation	1	42	Mean Difference (IV, Fixed, 95% CI)	4.0 [‐4.04, 12.04]
9 Hospital readmission in 30 d	0	0	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Adverse events/side effects	3	110	Odds Ratio (M‐H, Random, 95% CI)	1.65 [0.42, 6.48]