Table 2.

Sample cohorts. A list of each strain and age cohort analysed in the ELISA, including the number of animals of each gender within each cohort at 3, 4, 6, 9, and 12 months (m). Mean serum and brain C1q levels are reported in microgrammes per millilitre and nanogrammes per microgramme total brain lysate protein (± sd), respectively. No significant differences in gender were found in any of the mouse lines (non-significant; ns). n/a, not applicable

	Genotype	Age	Male	Female	C1q (mean ± sd)	Gender difference
Serum	WT	3 m	6	4	72.45 ± 15.25	Ns
		6 m	5	5	64.76 ± 8.95	Ns
		9 m	4	6	59.91 ± 16.11	Ns
		12 m	5	7	55.54 ± 12.38	Ns
	APPNL-G-F	3 m	5	5	56.01 ± 16.54	Ns
		6 m	5	4	43.08 ± 6.31	Ns
		9 m	4	6	40.42 ± 12.98	Ns
		12 m	4	6	40.16 ± 9.55	Ns
	3xTg	4 m	4	0	46.95 ± 17.50	n/a
		12 m	5	0	32.86 ± 11.07	n/a
	C3 KO	6 m	3	4	39.41 ± 7.08	Ns
		12 m	4	3	41.92 ± 6.20	Ns
	C7 KO	6 m	5	4	49.51 ± 15.01	Ns
		12 m	5	5	32.84 ± 8.30	Ns
	Crry KO	6 m	6	6	68.31 ± 25.70	Ns
		12 m	5	4	56.87 ± 16.81	Ns
	C1q KO	6 m	6	5	n/a	n/a
		12 m	4	4	n/a	n/a
	Rat	3 m	11	0	97.69 ± 14.31	n/a
Brain	WT	3 m	4	4	0.285 ± 0.039	ns
		12 m	4	4	0.353 ± 0.043	ns
	APPNL-G-F	3 m	4	4	0.234 ± 0.013	ns
		12 m	4	4	0.386 ± 0.024	ns