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. 2021 Oct 2;7:272. doi: 10.1038/s41420-021-00659-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b CCK-8 and representative colony formation assays were conducted to examine the effects of TIPE knockdown on the proliferation and colony formation of HCT116 cells. *p < 0.05; **p < 0.01; ****p < 0.0001. c The shCtrl and shTIPE HCT116 cells were labeled with ROS and Lipid ROS probes, the levels of ROS and Lipid ROS were detected by flow cytometry and analyzed statistically. Data are presented as the mean ± SD. *p < 0.05; **p < 0.01; ****p < 0.0001.