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. 2021 Oct 2;12(10):901. doi: 10.1038/s41419-021-04155-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Volcano plot of differential genes expression after PLEK2 was stably knockdown in KYSE-30 cells. B The Venn diagram showed number of differential upregulated genes in PLEK2 stably knockdown cells; C The Venn diagram showed number of differential downregulated genes in PLEK2 stably knockdown cells; D The expression of PLEK2 and LCN2 in PLEK2 knockdown KYSE-450 cells on the mRNA level; E The expression of PLEK2 and LCN2 in PLEK2 knockdown KYSE-30 cells on the mRNA level; F The expression of PLEK2 and LCN2 in PLEK2 knockdown KYSE-30 and KYSE-450 tested by western blot. The expression of LCN2 in PLEK2 knockdown cells which treated with TGF-β on the mRNA level; G The migration and invasion ability of PLEK2 knockdown cells with or without LCN2 overexpression; H Overexpression of LCN2 in PLEK2 knockdown cells and its efficiencies were detected on the mRNA level; I Qualification of number of cells that migrated through the membrane or invaded through the membrane; J Western blot analysis of PLEK2 Claudin-1, AKT, p-AKT, and LCN2. Tubulin was used as loading control; K The expression of LCN2 in PLEK2 knockdown KYSE-30 which treated with TGF-β on the mRNA level; L The expression of LCN2 in PLEK2 knockdown KYSE-450 which treated with TGF-β on the mRNA level; *P < 0.01; ***P < 0.01; ***P < 0.001.