Table 3:

LncRNAs dysregulated by polycyclic aromatic hydrocarbons and their metabolites exposures.

Carcinogens	LncRNAs	Cancers	Models	Upstream genes	Downstream genes	Phenotype	References
Anti-BPDE	AF118081 (↑)	Lung cancer	Human 16HBE cells, lung cancer cell lines, mice, human lung cancer tissues	–	–	Promote cell proliferation, migration and invasion, promote tumorigenesis in vivo	[87]
Anti-BPDE	LOC728228 (↑)	Lung cancer	Human 16HBE cells, lung cancer cell lines, mice	–	CCND1	Promote G1/S transition, cell proliferation and migration, promote tumorigenesis in vivo	[88]
B[a]P	LncRNA-DQ786227 (↑)	Lung cancer	Human BEAS-2B cells, lung cancer cell lines, mice	–	–	Promote cell proliferation and inhibit apoptosis, promote tumorigenesis in vivo	[86]
PAH	HOTAIR (↑)	Lung cancer	Human blood	–	–	Promote PAH-induced DNA damage	[89]
	MALAT1 (↑)	Lung cancer	Human blood	–	–	Promote PAH-induced DNA damage	[89]

(↑) Upregulation; (↓) Downregulation after exposure of environmental carcinogens; Anti-BPDE, Anti-benzo[a]pyrene-7,8-diol-910-epoxide; BaP, benzo[a]pyrene; PAH, Polycyclic aromatic hydrocarbon.