Table 4:

LncRNAs dysregulated by ultraviolet and ionizing radiation exposures.

Carcinogens	LncRNAs	Cancers	Models	Upstream genes	Downstream genes	Phenotype	References
Medical occupational radiation	ENST00000516478, NR_024380 (↓)	Thyroid cancer	Human thyroid carcinoma	–	–	Decreased levels in patients with occupational exposure to radiation	[96]
	LncRNA n335243, n335249, n336302, ENST00000509033 (↑)	Thyroid cancer	Human thyroid carcinoma	–	–	Increased levels in patients with occupational exposure to radiation	[96]
UV irradiation	AC005971.3 (↓)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	CENPV	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	AC068302.3 (↑)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	MFI2	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	BC028022 (↓)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	FAM111A	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	CYP17A10S (↓)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	CYP17A1	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	Lnc-CD1D-2:1 (↑)	Non-melanoma skin cancer	Human primary melanocytes	–	p38	Involved in UVB-induced melanogenesis	[92]
	Lnc-GKN2–1:1 (↑)	Non-melanoma skin cancer	Human primary melanocytes	–	–	Involved in UVB-induced melanogenesis	[92]
	RP11–137J7.2 (↑)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	NMBR	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	RP11–62121.1 (↑)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	KIF26B	Increased expression in UV-irradiated non-melanoma skin cancer	[93]
	RP11–656D10.6 (↑)	Non-melanoma skin cancer	Human primary epidermal keratinocytes	–	DEM1	Increased expression in UV-irradiated non-melanoma skin cancer	[93]

(↑) Upregulation; (↓) Downregulation after exposure of environmental carcinogens; UV, Ultraviolet.