Table 3.
Univariate and multivariate Cox regression analysis of initial 3 point decrease of QMGS
| Parameters | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Sex | ||||
| Male | Ref. | – | ||
| Female | 0.92 (0.76 to 1.12) | 0.405 | ||
| Age, years | ||||
| < 42 | Ref. | – | Ref. | – |
| ≥ 42 | 0.55 (0.45 to 0.67) | < 0.001 | 0.55 (0.45 to 0.67) | < 0.001 |
| Disease course, months | ||||
| < 8 | Ref. | – | ||
| ≥ 8 | 0.91 (0.75 to 1.10) | 0.334 | ||
| Preoperative steroids | ||||
| No | Ref. | – | ||
| Yes | 1.10 (0.90 to 1.34) | 0.366 | ||
| MGFA class | ||||
| I + IIA | Ref. | – | Ref. | – |
| IIB–V | 0.75 (0.60 to 0.94) | 0.012 | 0.82 (0.66 to 1.03) | 0.088 |
| Surgical approach | ||||
| Sternotomy | Ref. | – | ||
| VATS | 1.05 (0.76 to 1.46) | 0.771 | ||
| Masaoka-Koga stage | ||||
| I | Ref. | – | Ref. | – |
| IIa–IIIa | 0.66 (0.48 to 0.90) | 0.010 | 0.65 (0.47 to 0.89) | 0.008 |
| WHO pathologic type | ||||
| A + AB | Ref. | – | ||
| B1–B3 | 0.97 (0.74 to 1.27) | 0.842 | ||
| Tumor size | ||||
| ≤ 5 cm | Ref. | – | ||
| > 5 cm | 0.75 (0.56 to 1.01) | 0.057 | ||
| Complete resection | ||||
| No | Ref. | – | ||
| Yes | 1.61 (0.95 to 2.75) | 0.079 | ||
CI, confidence interval; HR, hazard ratio; MGFA, Myasthenia Gravis Foundation of America; QMGS, Quantitative Myasthenia Gravis Score; VATS, video-assisted thoracoscopic surgery; WHO, World Health Organization