Fig. 1.
Cell type landscape of human tooth germ. A Oral panorama of two tooth germ samples at stage A and D used for scRNA-sEq. Schematics indicated the detail structure of tooth germ. Boxes indicated location of immunofluorescence (F, G). B UMAP projection of cell clustering results. C Proportion of each cell cluster in stage A and D tooth germ. D Expression patterns of selected cell markers. E Refined subtypes and their markers for SOX9+ cells and osteoblast. F, G Immunofluorescence result for SPARC and GJA1 expression in tooth germ