Table 3.

Univariate and multivariate Cox regression analysis of prognostic factors for RFS in the validation set

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.003 (0.980–1.027)	0.782	1.003 (0.979–1.028)	0.826
Sex	0.948 (0.604–1.486)	0.914	0.935 (0.577–1.516)	0.786
Tumor size	0.967 (0.894–1.046)	0.405	0.996 (0.919–1.079)	0.916
Hsa_circ_0005092	1.831 (1.388–2.416)	0.000***	1.437 (1.015–2.033)	0.041*
Hsa_circ_0002647	1.979 (1.475–2.655)	0.007**	1.565 (1.066–2.300)	0.022*

RFS recurrence-free survival, HR Hazard ratio, CI confidence interval

*p < 0.05, **p < 0.01, ***p < 0.001