Table 2.
the cytotoxicity of cisplatin, in A2780/RCIS, multidrug-resistant ovarian carcinoma cells (MRP2-overexpressing ovarian carcinoma cell line) alone or in the presence of compounds
| Compound | A2780/RCIS IC50a (μM) | Compound | A2780/RCIS IC50a (μM) |
|---|---|---|---|
| Cis +4a | 53.62±3.45 | Cis +6a | 64.55±1.7 |
| Cis +4b | 63.21±2.96 | Cis +6b | 62.84±2.1 |
| Cis +4c | 37.34±3.87 | Cis +6c | 56.27±3.8 |
| Cis +4d | 52.67±4.36 | Cis +6d | 35.54±0.9 |
| Cis +5a | 45.23±4.12 | Cis +7a | 48.06±0.51 |
| Cis +5b | 48.34±3.35 | Cis +7b | 25.17±1.6 |
| Cis +5c | 28.56±5.34 | Cis +7c | ND |
| Cis +5d | 54.34±3.95 | Cis +7d | 14.88±1.1 |
| Cisplatin | 57.67±4.61 |