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. Author manuscript; available in PMC: 2022 Jul 21.
Published in final edited form as: ACS Chem Neurosci. 2021 Jul 2;12(14):2693–2704. doi: 10.1021/acschemneuro.1c00345

Figure 4.

Figure 4.

Compound 3 is a partial antagonist of nAChRs expressed in X. laevis oocytes, as determined by electrophysiology. The x-axis is log [3], while the y-axis is the response to ACh at varying [3], in comparison to ACh without 3, given as the mean ± SEM from at least four separate oocytes. Ranges in parentheses are 95% confidence intervals. A) Mouse α3β4 nAChR, IC50 1.43 (0.4 – 5.1) μM, Hill slope 0.89 (0.20 −2.0). B) Rat α6/α3β4 nAChR, IC50 1.4 (1.9 – 5.0) μM, Hill slope 1.3 (0.67 - 1.90).