Table 2.
Individual T codes associated with the probable DILI and non-DILI casesa
| ICD-10 T codes | Probable DILI (N = 121) | Non-DILI (N = 61) |
|---|---|---|
|
| ||
| T36 systemic antibiotics | 28 (23.1) | 13 (21.3) |
| T37 systemic anti-infectives and antiparasitics | 8 (6.6) | 1 (1.6) |
| T38 hormones, synthetic substitutes and antagonists | 10 (8.3) | 5 (8.2) |
| T39 nonopioid analgesicsb | 6 (5) | 3 (4.9) |
| T40 narcotics and psychodysleptics, hallucinogens | 5 (4.1) | 3 (4.9) |
| T41 anesthetics and therapeutic gases | 2 (1.7) | 2 (3.3) |
| T43 psychotropic drugs, not otherwise specified | 2 (1.7) | 3 (4.9) |
| T44 drugs affecting autonomic nervous system | 1 (0.8) | 0 |
| T45 hematologic drugs | 31 (25.6) | 12 (19.7) |
| T46 cardiovascular drugs | 0 | 5 (8.2) |
| T50 diuretics and other drugs, not otherwise specified | 28 (23.1) | 14 (22.9) |
Data are presented as N (%) unless otherwise indicated
DILI drug-induced liver injury, ICD-10 International Classification of Diseases, Tenth Revision
All acetaminophen hepatotoxicity cases (N = 75) were excluded using ICD-10 code T39.1 for 4-aminophenol derivatives
The culprit drugs most frequently captured by each T code were as follows: T36—amoxicillin-clavulanate (six), trimethoprim-sulfamethoxazole (six), piperacillin-tazobactam (five), azithromycin (four), cephalosporins (four); T37—trimethoprim-sulfamethoxazole (two), isoniazid (two); T38—pembrolizumab (two), ipilimumab (two); T39—diclofenac (one), ibuprofen (one), leflunomide (one); T40—cocaine (one), tramadol (one); T41—isoflurane (one), valproic acid (one); T43—cocaine (one), venlafaxine (one); T44—allopurinol (one); T45—pembrolizumab (four), methotrexate (four), asparaginase (three); and T50—nivolumab (nine), herbal supplements (five), ipilimumab (four)