Table 1.
Demographics and prevalence of signs and symptoms
| Characteristic | Total (n = 300) | Parotitis (n = 140, 47%) | No history of parotitis (n = 160, 53%) | P a |
|---|---|---|---|---|
| Age at diagnosis, median years (IQR) | 12 (9,15) | 11 (8, 13) | 14 (11.5, 16) | <0.001 |
| Age range | 1–17.8 | 1–17.5 | 5–17.8 | |
| Age at database entry, median years (IQR) | 17 (14,20) | 16 (13,19.3) | 17 (15,20.8) | 0.47 |
| Age range | 5–32 | 5–32 | 7.8–32 | |
| Female, n (%) | 250 (83%) | 110 (79%) | 140 (88%) | 0.04 |
| Anticholinergic use, n (%) | 0 (%) | 0 (%) | 0 (%) | N/A |
| Past medical history | n (%) | n (%) | n (%) | P a |
| Systemic lupus | 25 (8%) | 12 (9%) | 13 (8%) | 0.89 |
| Other connective tissue diseases | 19 (6%) | 6 (4%) | 13 (8%) | 0.17 |
| Lymphoma | 5 (2%) | 4 (3%) | 1 (<1%) | 0.13 |
| HIV/Sarcoidosis/IgG4-related disease/graft vs host | 0 (0%) | 0 (0%) | 0 (0%) | N/A |
| Prior head and neck radiation | 1 (<1%) | 0 (0%) | 1 (<1%) | 0.35 |
| Symptoms | n (%) | n (%) | n (%) | P a |
| Sicca | ||||
| Dry eyes or dry mouth | 194 (65%) | 88 (63%) | 106 (66%) | 0.54 |
| Dry mouth | 156 (52%) | 74 (53%) | 82 (51%) | 0.78 |
| Dry eyes | 144 (48%) | 64 (46%) | 80 (50%) | 0.46 |
| Dry eyes and dry mouth | 106 (35%) | 50 (36%) | 56 (35%) | 0.90 |
| Non-sicca | ||||
| Arthralgia, n (%) | 161 (54%) | 59 (42%) | 102 (64%) | <0.001 |
| Recurrent or persistent parotitis | 140 (47%) | |||
| Arthritis | 71 (24%) | 27 (19%) | 44 (28%) | 0.10 |
| Lymphadenopathy | 54 (18%) | 33 (24%) | 21 (13%) | 0.02 |
| Cytopenia | 52 (17%) | 20 (14%) | 32 (20%) | 0.19 |
| Fevers | 34 (11%) | 19 (14%) | 15 (9%) | 0.25 |
| Cutaneous vasculitis | 27 (9%) | 12 (9%) | 15 (9%) | 0.81 |
| Weight loss | 26 (9%) | 8 (6%) | 18 (11%) | 0.09 |
| Pulmonary | 25 (8%) | 11 (8%) | 14 (9%) | 0.78 |
| Headache | 20 (7%) | 9 (6%) | 11 (7%) | 0.88 |
| Proteinuria | 18 (6%) | 8 (6%) | 10 (6%) | 0.85 |
| Peripheral neuropathy | 17 (6%) | 6(4%) | 11 (7%) | 0.33 |
| Vaginitis | 14 (5%) | 9 (6%) | 5 (3%) | 0.18 |
| Myositis | 9 (3%) | 3 (2%) | 6 (4%) | 0.42 |
| Other neurologic symptomsb | 7 (2%) | 3 (2%) | 4 (3%) | 0.84 |
| Interstitial nephritis | 6 (2%) | 1 (<1%) | 5 (3%) | 0.14 |
| Seizures | 5 (2%) | 4 (3 %) | 1 (<1%) | 0.13 |
| Transverse myelitis/neuro-myelitis optica spectrum | 5 (2%) | 0 (0%) | 5 (3%) | 0.04 |
| Renal tubular acidosis | 3 (1%) | 2 (1%) | 1 (<1%) | 0.49 |
a
P-value represents the significance of a χ2 analysis comparing patients with and without parotitis by each characteristic.
b
Includes CNS vasculitis, psychosis, anxiety, depression, fatigue, tic disorder.
IQR: interquartile range; HIV: human immunodeficiency virus.