Table 2.
Distribution of mtDNA and sPG I/II ratio in various demographic and clinicopathologic subgroups
| Variables | mtDNA-CN (Mean ± SD) | sPG I/II (Mean ± SD) | ||||||
|---|---|---|---|---|---|---|---|---|
| GC | Non-GC | CG | NM | GC | Non-GC | Gastritis | NM | |
| Age | ||||||||
| < 60 | 4.1 ± 2.9 | 2.9 ± 2.4 | 3.6 ± 2.8 | 2.4 ± 1.8 | 5.9 ± 4.7 | 10.4 ± 5.5 | 9.1 ± 4.4 | 11.3 ± 6.2 |
| ≥ 60 | 6.1 ± 3.8 | 2.7 ± 2.1 | 3.2 ± 2.2 | 2.0 ± 1.9 | 5.8 ± 2.9 | 8.4 ± 4.5 | 7.1 ± 4.7 | 10.4 ± 3.5 |
| p value | 0.031 | 0.643 | 0.500 | 0.459 | 0.939 | 0.030 | 0.048 | 0.517 |
| Gender | ||||||||
| Female | 3.7 ± 3.2 | 2.9 ± 2.0 | 3.6 ± 2.1 | 2.2 ± 1.7 | 4.5 ± 3.2 | 10.3 ± 5.5 | 8.8 ± 4.3 | 11.8 ± 6.2 |
| Male | 5.3 ± 3.5 | 2.8 ± 2.5 | 3.3 ± 3.0 | 2.4 ± 1.9 | 6.2 ± 4.1 | 9.5 ± 5.1 | 8.2 ± 4.8 | 10.5 ± 5.3 |
| p value | 0.146 | 0.737 | 0.563 | 0.582 | 0.261 | 0.310 | 0.493 | 0.267 |
| Ethnicity | ||||||||
| Fars | 4.7 ± 2.6 | 2.8 ± 2.1 | 3.3 ± 2.3 | 2.2 ± 1.7 | 3.3 ± 1.9 | 9.5 ± 5.2 | 8.5 ± 4.5 | 10.4 ± 5.8 |
| Non-Fars | 5.0 ± 3.6 | 2.9 ± 2.4 | 3.5 ± 2.8 | 2.4 ± 1.9 | 6.2 ± 4.0 | 10.2 ± 5.4 | 8.5 ± 4.6 | 11.7 ± 5.7 |
| p value | 0.777 | 0.709 | 0.699 | 0.681 | 0.152 | 0.319 | 0.958 | 0.270 |
| H. pylori serology | ||||||||
| Negative | 4.7 ± 3.6 | 2.8 ± 2.2 | 3.6 ± 2.4 | 2.5 ± 1.9 | 4.8 ± 3.6 | 11.3 ± 5.3 | 9.7 ± 5.0 | 12.1 ± 5.4 |
| Positive | 5.0 ± 3.4 | 2.9 ± 2.4 | 3.4 ± 2.7 | 2.0 ± 1.6 | 5.1 ± 3.4 | 8.8 ± 5.1 | 7.2 ± 3.8 | 10.0 ± 6.2 |
| p value | 0.707 | 0.970 | 0.918 | 0.471 | 0.707 | 0.003 | 0.217 | 0.131 |
| Smoking | ||||||||
| Never | 4.7 ± 3.3 | 2.8 ± 2.2 | 3.3 ± 2.4 | 2.2 ± 1.7 | 6.1 ± 3.4 | 9.9 ± 5.4 | 8.3 ± 4.2 | 11.5 ± 5.9 |
| Ever | 5.2 ± 3.5 | 3.0 ± 2.6 | 3.8 ± 3.1 | 2.5 ± 2.0 | 5.9 ± 3.4 | 9.9 ± 5.3 | 9.2 ± 5.5 | 10.3 ± 5.4 |
| p value | 0.644 | 0.496 | 0.454 | 0.443 | 0.865 | 0.992 | 0.421 | 0.288 |
| FHGC | ||||||||
| No | 4.5 ± 3.0 | 2.9 ± 2.4 | 3.5 ± 2.7 | 2.3 ± 1.8 | 5.4 ± 3.8 | 9.9 ± 5.5 | 8.4 ± 4.6 | 11.3 ± 5.9 |
| Yes | 7.7 ± 4.8 | 2.8 ± 1.9 | 3.2 ± 1.8 | 2.4 ± 2.1 | 6.2 ± 2.3 | 10 ± 4.5 | 8.9 ± 4.5 | 11.3 ± 5.4 |
| p value | 0.017 | 0.949 | 0.745 | 0.826 | 0.586 | 0.930 | 0.765 | 0.980 |
| Inflammation grade | ||||||||
| 0 | - | 1.8 ± 1.3 | - | 1.9 ± 1.3 | - | 11.1 ± 6.2 | - | 11.1 ± 6.2 |
| I | - | 2.5 ± 2.0 | 1.1 ± 0.8 | 2.6 ± 2.0 | - | 10.8 ± 4.9 | 9.4 ± 6.1 | 10.8 ± 4.9 |
| II | - | 3.8 ± 2.6 | 3.9 ± 2.6 | - | - | 8.2 ± 5.0 | 8.3 ± 5.1 | - |
| III | - | 2.3 ± 1.6 | 2.3 ± 1.6 | - | - | 8.7 ± 2.3 | 8.7 ± 2.3 | - |
| IV | - | 3.0 ± 2.8 | 3.0 ± 2.8 | - | - | 12.1 ± 6.5 | 11.3 ± 6.9 | - |
| p value | - | 0.0001 | 0.029 | 0.05 | - | 0.007 | 0.315 | 0.761 |
| Atrophy grade | ||||||||
| 0 | - | 2.9 ± 2.2 | 4.2 ± 2.4 | 2.3 ± 1.8 | - | 10.1 ± 5.4 | 8.5 ± 5.1 | 10.9 ± 5.5 |
| I | - | 2.3 ± 2.1 | 1.8 ± 0 | 2.4 ± 2.3 | - | 10.8 ± 3.5 | 5.9 ± 0 | 11.6 ± 3.0 |
| II | - | 2.5 ± 2.5 | 2.5 ± 2.5 | - | - | 9.1 ± 5.7 | 8.9 ± 5.8 | - |
| III | - | 2.9 ± 2.9 | 2.9 ± 2.9 | - | - | 9.4 ± 4.4 | 9.4 ± 4.4 | - |
| IV | - | 3.2 ± 0 | 3.2 ± 0 | - | - | - | - | - |
| P value | - | 0.833 | 0.042 | 0.894 | - | 0.734 | 0.881 | 0.758 |
| Tumor subsite | ||||||||
| Cardia | 4.6 ± 3.1 | - | - | - | 4.1 ± 2.9 | - | - | - |
| Non-cardia | 4.7 ± 3.3 | - | - | - | 6.5 ± 4.2 | - | - | - |
| Mixed | 4.1 ± 3.9 | - | - | - | 2.4 ± 0 | - | - | - |
| p value | 0.020 | - | - | - | 0.320 | - | - | - |
| Tumor stage | ||||||||
| IA | 7.8 ± 0 | - | - | - | 5.3 ± 0 | - | - | - |
| IB | 3.4 ± 1.9 | - | - | - | 3.7 ± 2 | - | - | - |
| II | 7.1 ± 3.7 | - | - | - | 5.4 ± 2.8 | - | - | - |
| IIIA | 5.8 ± 4.2 | - | - | - | 7.7 ± 4.4 | - | - | - |
| IIIB | 3.4 ± 1.7 | - | - | - | 5.9 ± 5.0 | - | - | - |
| IV | 3.8 ± 1.9 | - | - | - | 6.2 ± 4.9 | - | - | - |
| p value | 0.034 | - | - | - | 0.683 | - | - | - |
| Tumor grade | ||||||||
| Undifferentiated | 5.0 ± 0 | - | - | - | 11.3 ± 0 | - | - | - |
| Poorly differentiated | 3.7 ± 2.1 | - | - | - | 4.4 ± 4.8 | - | - | - |
| Moderately differentiated | 6.1 ± 4.5 | - | - | - | 5.6 ± 3.2 | - | - | - |
| Well differentiated | 5.8 ± 3.2 | - | - | - | 5.9 ± 3.9 | - | - | - |
| p value | 0.168 | - | - | - | 0.595 | - | - | - |
| Tumor type | ||||||||
| Intestinal | 5.3 ± 3.3 | - | - | - | 5.5 ± 3.2 | - | - | - |
| Diffuse | 3.4 ± 2.8 | - | - | - | 5.7 ± 5.8 | - | - | - |
| Signet ring cell | 2.0 ± 0 | - | - | - | 3.2 ± 0 | - | - | - |
| Mixed | 5.1 ± 1.7 | - | - | - | 2.6 ± 1.3 | - | - | - |
| P value | 0.320 | - | - | - | 0.454 | - | - | - |