Table 4.

Single and double assessment of mtDNA-CN and sPG I/II ratio in risk screening

	Risk variables					OR (95% CI)
A	mtDNA	sPGI/II		GC	Non-GC	Crude	p value	Adjusted	p value
Single	low	-		19	143	Ref	-	Ref
	high	-		34	64	4.0 (2.1, 7.5)	< 0.001	3.0 (1.4, 6.4)	0.004
	-	high		16	130	Ref	-	Ref	-
	-	low		28	74	3.1 (1.6, 6.1)	0.001	3.2 (1.4, 7.2)	0.006
Double	low	high		4	89	Ref	-	Ref	-
	low	low		10	51	4.4 (1.3 to 14.6)	0.017	7.4 (1.6, 33.9)	0.011
	high	high		14	41	7.6 (2.4 to 24.5)	0.001	8.0 (1.9, 34.2)	0.002
	high	low		16	22	15.5 (4.7, 50.8)	< 0.001	27.1 (5.0, 147.3)	< 0.001
B	mtDNA	sPGI/II		GC	CG	Crude	p value	Adjusted	p value
Single	low	-		15	53	Ref	-	Ref	-
	high	-		38	51	2.5 (1.2, 5.2)	0.011	2.0 (0.9, 4.5)	0.114
	-	high		13	48	Ref	-	Ref	-
	-	low		31	54	2.1 (1.0, 4.5)	0.053	2.3 (0.9, 5.6)	0.076
Double	low	high		4	34	Ref	-	Ref	-
	low	low		10	28	3.0 (0.9, 10.7)	0.085	5.6 (1.2, 27.0)	0.033
	high	high		14	32	5.4 (1.6, 18.6)	0.006	6.8 (1.4, 32.9)	0.017
	high	low		16	18	7.6 (2.2, 26.0)	0.001	13.1 (2.4, 72.6)	0.003
C	mtDNA	sPGI/II		GC	NM	Crude	p value	Adjusted	p value
Single	low	-		15	73	Ref	-	Ref	-
	high	-		38	29	6.6 (3.1, 13.7)	<0.001	5.2 (2.2, 12.3)	<0.001
	-	high		13	68	Ref	-	Ref	-
	-	low		31	34	4.7 (2.2, 10.1)	<0.001	3.8 (1.5, 9.7)	0.004
Double	low	high		4	55	Ref	-	Ref	-
	low	low		10	23	6.0 (1.7, 21.0)	0.005	8.5 (1.8, 40.5)	0.007
	high	high		14	19	10.1 (3.0, 34.6)	<0.001	11.7 (2.3, 58.4)	0.003
	high	low		16	5	44.0 (10.6, 183.5)	<0.001	49.5 (7.9, 311.6)	<0.001
D	mtDNA	sPGI/II		CG	NM	Crude	p value	Adjusted	p value
Single	low	-		53	73	Ref	-	Ref	-
	high	-		51	29	2.6 (1.5, 4.6)	0.001	2.7 (1.4, 5.2)	0.004
	-	high		48	68	Ref	-	Ref	-
	-	low		54	34	2.2 (1.3, 3.9)	0.006	1.7 (0.9, 3.2)	0.104
Double	low	high		34	55	Ref	-	Ref	-
	low	low		28	23	2..0 (1.0, 4.0)	0.057	1.5 (0.7, 3.4)	0.303
	high	high		32	19	1.9 (0.9, 4.0)	0.100	1.7 (0.7, 4.0)	0.219
	high	low		18	5	5.8 (2.0, 17.1)	0.001	3.8 (0.9, 15.3)	0.063

*Adjusted for age, gender, ethnicity, H. pylori serostatus, smoking, and FHGC. OR, odds ratio; CI, confidence interval