Table 1. Differentially overexpressed transcripts associated with innate immunity induced by cooperative Ras-p53 mutations.
| ELR Chemokines |
|---|
| CXCL1 |
| CXCL2 |
| CXCL3 |
| CXCL6 |
| Pro-Inflammatory Ligands |
| IL1B |
| IL6 |
| IL8 |
| CSF2 |
| Extracellular Matrix-related Genes |
| MMP3 |
| CLECSF2 |
Data from Buganim et al. demonstrating increased expression of selected chemokines (i.e., CXCL1, CXCL2, CXCL3, and CXCL6) and pro-inflammatory ligands (i.e., IL1B, IL6, IL8, and CSF2) from immortalized human fibroblasts transduced with RasG12V and p53R175H mutant constructs [24].