Table 2. Top 10 most abundant cell-surface proteins found upregulated or solely expressed/detected in 2D-cultured NCI-H23 cells.
| UniProt
Acc # |
Gene | Protein description | 2D culture
regulation |
Expression in tumor | Expression reference |
|---|---|---|---|---|---|
| P21589 | NT5E | 5′-nucleotidase (CD73) | Detected in 2D only | Parenchyma | BMC Cancer. 2020; 20:411. |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Detected in 2D only | Parenchyma | Tumour Biol. 2017; 39:1010428317691000. |
| P42702 | LIFR | Leukemia inhibitory factor receptor (CD118) | Detected in 2D only | Parenchyma | Cancer Res. 2007; 67:2131–40. |
| P08582 | MELTF | Melanotransferrin (CD228) | Detected in 2D only | Stroma | Exp Cell Res. 2007; 313:2910–19. |
| P41440 | SLC19A1 | Folate transporter 1 | Detected in 2D only | Parenchyma | Oncotarget. 2018; 9:16807–21. |
| P35613 | BSG | Basigin (CD147) | Upregulated in 2D | Parenchyma | Oncotarget. 2018; 9:26431–52. |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor (CD221) | Upregulated in 2D | Parenchyma | Sci Transl Med. 2019; 11:eaaw7999. |
| P17301 | ITGA2 | Integrin alpha-2 (CD49b) | Upregulated in 2D | Parenchyma | Gene. 2018; 643:74–82. |
| P23229 | ITGA6 | Integrin alpha-6 (CD49f) | Upregulated in 2D | Parenchyma | Mol Ther Nucleic Acids. 2019; 18:774–86. |
| P05362 | ICAM1 | Intercellular adhesion molecule 1 (CD54) | Upregulated in 2D | Parenchyma and Stroma | Virchows Arch. 1996; 428:21–27. |
Annotations accessible