Table 2.
Univariable and multivariable predictors for premature discontinuation of AFP after HCT (N = 303).1
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| Predictor2 | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age group, years | ||||||
| 18–39 | Reference | |||||
| 40–64 | 0.68 | (0.39, 1.18) | 0.170 | |||
| 64+ | 0.87 | (0.47, 1.59) | 0.646 | |||
| Sex | ||||||
| Female | Reference | |||||
| Male | 0.73 | (0.50, 1.08) | 0.119 | |||
| Race | ||||||
| White | ||||||
| Black | 1.74 | (0.90, 3.37) | 0.098 | |||
| Asian | 2.21 | (1.11, 4.41) | 0.025 | |||
| Other | 2.87 | (1.44, 5.74) | 0.003 | |||
| Donor type | ||||||
| Matched | Reference | |||||
| Mismatched | 1.67 | (1.11, 2.52) | 0.015 | |||
| Haploidentical | 0.91 | (0.39, 2.10) | 0.818 | |||
| Stem cell source | ||||||
| Marrow | Reference | |||||
| Cord blood | 2.24 | (1.07, 4.66) | 0.031 | |||
| Peripheral blood | 1.19 | (0.61, 2.31) | 0.613 | |||
| GvHD prophylaxis | ||||||
| TAC or Sirolimus + MMF | Reference | Reference | ||||
| Cyclosporin + MMF | 1.89 | (1.16, 3.08) | 0.011 | 1.94 | (1.17, 3.21) | 0.010 |
| CD34+ selection | 0.95 | (0.61, 1.49) | 0.829 | 1.01 | (0.64, 1.60) | 0.954 |
| Recipient CMV serostatus | ||||||
| Negative | reference | |||||
| Positive | 1.23 | (0.83, 1.81) | 0.298 | |||
| Donor CMV serostatus | ||||||
| Negative | Reference | Reference | ||||
| Positive | 1.29 | (0.88, 1.90) | 0.189 | 1.41 | (0.95, 2.09) | 0.093 |
| aGvHD grade 3 | ||||||
| 0–1 | Reference | Reference | ||||
| 2–4 | 1.63 | (1.10, 2.40) | 0.014 | 1.62 | (1.08, 2.45) | 0.021 |
| Antifungal prophylaxis | ||||||
| Voriconazole | Reference | Reference | ||||
| Isavuconazole | 0.27 | (0.15, 0.48) | < 0.0001 | 0.26 | (0.15, 0.46) | < 0.0001 |
1
Two patients with unknown aGvHD grade were excluded.
2
Variables with P-value < 0.3 in the univariable models are shown. Underlying disease and conditioning intensity were not included in the model.
3
aGvHD was included as time-dependent covariate.
HCT: Hematopoietic cell transplant; HR: Hazard ratio, MDS: Myelodysplastic syndrome.