FIGURE 2.

Treatment with gefitinib plus anlotinib synergistically inhibited proliferation of PC9/GR cells. (a, b) EdU proliferation assays were performed 48 h after treatment with gefitinib, anlotinib, and gefitinib plus anlotinib. (c, d) Colony‐formation assays were performed to analyze the colony‐formation efficiency of PC9/GR cells in the different treatment groups. Results are shown as mean ± SD of three independent experiments performed in triplicate. Significance levels determined using the t test are indicated (ns, not significant compared with the control group. *p < 0.01, **p < 0.001 compared with the control group. #p < 0.01, ##p < 0.001 compared with the gefitinib group)