Table 3.
Associations between clinical diagnoses during pregnancy and neonatal telomere length.
| Model 1: crude associations | Model 2: further adjusted for maternal demographics and newborn characteristics+ | Model 3: further adjusted for maternal risk behaviors and mental component of quality of life# | Model 4: further adjusted for each other$ | |||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
| Maternal health complication during pregnancy | ||||||||
| Maternal infection | -0.16 (-0.31, -0.005) | 0.042 | -0.17 (-0.33, -0.02) | 0.027 | -0.17 (-0.33, -0.02) | 0.028 | -0.18 (-0.33, -0.02) | 0.026 |
| Anaemia | -0.02 (-0.17, 0.14) | 0.831 | 0.00 (-0.16, 0.15) | 0.987 | 0.00 (-0.16, 0.16) | 0.999 | -0.01 (-0.17, 0.14) | 0.870 |
| Hypertension | -0.15 (-0.45, 0.16) | 0.344 | -0.16 (-0.47, 0.14) | 0.287 | -0.16 (-0.47, 0.14) | 0.294 | -0.17 (-0.47, 0.13) | 0.269 |
| Any two of the above diagnoses | -0.28 (-0.53, -0.04) | 0.023 | -0.29 (-0.53, -0.05) | 0.020 | -0.29 (-0.53, -0.04) | 0.021 | — | — |
| Complication at delivery | ||||||||
| Unspecific complications | -0.08 (-0.22, 0.07) | 0.287 | -0.08 (-0.22, 0.06) | 0.258 | -0.08 (-0.23, 0.06) | 0.260 | -0.09 (-0.23, 0.06) | 0.232 |
| Low birthweight | 0.03 (-0.29, 0.35) | 0.869 | 0.03 (-0.29, 0.35) | 0.842 | 0.03 (-0.29, 0.36) | 0.834 | 0.00 (-0.32, 0.33) | 0.976 |
| Neonatal jaundice | -0.12 (-0.33, 0.10) | 0.294 | -0.10 (-0.32, 0.12) | 0.366 | -0.10 (-0.32, 0.12) | 0.369 | -0.11 (-0.33, 0.11) | 0.325 |
| Any two of the above diagnoses | -0.14 (-0.44, 0.16) | 0.352 | -0.15 (-0.45, 0.15) | 0.317 | -0.15 (-0.45, 0.14) | 0.314 | — | — |
| Maternal health complication × child complication | ||||||||
| Maternal infection x unspecific complications at delivery | -0.23 (-0.41, -0.06) | 0.010 | -0.25 (-0.42, -0.07) | 0.006 | -0.25 (-0.42, -0.07) | 0.007 | — | — |
| Maternal infection × low birthweight | -0.17 (-0.72, 0.37) | 0.533 | -0.17 (-0.71, 0.38) | 0.543 | -0.16 (-0.71, 0.38) | 0.556 | — | — |
| Maternal infection × neonatal jaundice | -0.43 (-0.85, -0.01) | 0.045 | -0.45 (-0.88, -0.02) | 0.040 | -0.45 (-0.88, -0.02) | 0.040 | — | — |
+Further adjusted for mother's age, educational level, employment status, and infant's sex; #further adjusted for history of smoking, being drunk, drug usage of the mothers, and the mothers' mental component of quality of life; $further adjusted for each other's health complications.