Table 3.
Rate of Change in Lung Function Parameters (LFPs) Values (Ml/Year or %/Year for Predicted Values) Stratified by Radiological Evidence for Chronic Airway Disease
| LFPs | Total (n=115) | Without Radiological Evidence of Airway Disease (n=59) | With Radiological Evidence of Airway Disease (n=56) | p-value |
|---|---|---|---|---|
| Forced vital capacity (FVC) | ||||
| Pre-BD (L) | −37.55 (−159.88, 92.67) | −37.64 (−92.27, 123.63) | −36.98 (−219.7, 62.68) | 0.356 |
| Pre-BD (%) | −0.53 (−4.88, 4.55) | −0.6 (−4.19, 5) | −0.48 (−5.23, 3.18) | 0.549 |
| Post-BD (L) | −21.42 (−108.68, 80.7) | −18.55 (−95.51, 90.84) | −23.69 (−132.26, 74.05) | 0.650 |
| Post-BD (%) | 0.29 (−3.27, 4.23) | 0.72 (−1.92, 4.17) | 0 (−4.86, 5.14) | 0.640 |
| Forced expiratory volume in one second (FEV1) | ||||
| Pre-BD (L) | −18.74 (−102.49, 71.44) | −12.72 (−100.94, 77.41) | −19.67 (−112.79, 41.27) | 0.464 |
| Pre-BD (%) | −0.6 (−3.49, 4.13) | −0.6 (−3.49, 4.17) | −0.7 (−3.44, 3.63) | 0.511 |
| Post-BD (L) | −22.36 (−123.65, 61.66) | −37.95 (−126.97, 80.65) | −21.29 (−110.78, 60.91) | 0.724 |
| Post-BD (%) | −0.52 (−3.95, 4) | −0.61 (−3.85, 4.17) | −0.21 (−4.22, 3.9) | 0.967 |
| Excessive FEV1 (pre-BD) decline* | 65 (57) | 31 (53) | 34 (61) | 0.377 |
| FEV1/FVC | ||||
| Pre-BD (AV) | 0.00 (−0.03, 0.01) | 0.00 (−0.03, 0.01) | 0.00 (−0.03, 0.02) | 0.867 |
| Pre-BD (%) | 0.00 (−4.21, 1.83) | 0.00 (−2.87, 1.94) | −0.41 (−4.68, 1.71) | 0.518 |
| Post-BD (AV) | −0.01 (−0.03, 0.01) | −0.01 (−0.02, 0.01) | −0.01 (−0.03, 0.02) | 0.840 |
| Post-BD (%) | −0.46 (−3.77, 1.81) | −0.46 (−3, 1.63) | −0.43 (−4.66, 1.88) | 0.887 |
Notes: Data were median (IQR). P-values were obtained via Wilcoxon rank-sum test between patients with/without radiological evidence of airway disease for continuous parameters and chi-squared test for categorical parameters. *(Baseline predicted FEV1 – current predicted FEV1) + (0.15 x Baseline absolute FEV1).
Abbreviations: AV, absolute value; BD, bronchodilator.