Table 1.

Summary of the common generic and disease-specific PROs measures in cardiac surgery trials

Domain	Instrument	# of items	Time to complete	Score range	Dimensions
Generic quality of life	Short Form Health Survey (SF-12, SF-36)	12, 36	2–5 min	0–100*, mean (SD)	Physical functioning, role limitations due to physical problems, bodily pain, vitality, general health perception, social function, role limitations due to emotional problems, and mental health
	Euro-Qol-5D (EQ-5D)	5	1 min	Single index value: 0–1 Visual analog scale: 0–100*	Mobility, self-care, usual activity, pain or discomfort, and anxiety or depression
	PROMIS-Global Health	10	2 min	0–55, t-score	Physical function, fatigue, pain, emotional distress, and social health), and perceptions of general health
Disease-specific quality of life	Seattle Angina Questionnaire (SAQ)	19	5 min	0–100*, mean (SD)	Angina frequency, physical limitations, quality of life, angina stability, and treatment satisfaction
	Kansas City Cardiomyopathy Questionnaire (KCCQ)	23	5 min	0–100*, mean (SD)	Physical limitations, symptoms (frequency, severity and recent change over time), social limitations, self-efficacy, and quality of life
	Minnesota Living with Heart Failure Questionnaire (MLHFQ)	21	5 min	0–105, mean (SD)	Physical and emotional

^*higher score indicates better function