. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Curr Opin Insect Sci. 2021 May 24;47:82–89. doi: 10.1016/j.cois.2021.05.003

Table 1.

Conserved homologs of human kidney stone diseases in Drosophila melanogaster

Diseases	Human Mutation	Fly Ortholog	References

PH1/PH2	Slc26a6	dPrestin	[4^••,28^•]
Xanthinuria	Xdh	Xdh (rosy)	[5^••,40,41,42^•]
Uric Acid Stones	NHERF-1	Sip1	[42^•]
Primary hyperoxaluria type 1	AGXT	dAgxt	[4^••,36]
PH2	GRHPR	CG31674^a, unconfirmed	X
PH3	HOGA1	Unknown	X
Dent Disease Type 1	ClC-5	Clc-c, unconfirmed	X
Dent Disease Type 2	OCRL	OCRL, unconfirmed	x

CG31674 is most often predicted as a GRHPR-homolog but this is unconfirmed. Some algorithms do designate CG31674 as a HOGA1- homolog.