Table 2.

Adjusted and unadjusted differences (reference = HFrEF) in baseline physical function, quality of life, depression, and cognition in patients ≥60 years hospitalized with ADHF by heart failure phenotype.

	Unadjusted Analysis			Adjusted Analysis
	HFpEF (n=185)	HFrEF (n=164)	P-value	HFpEF (n=185)	HFrEF (n=164)	Group Difference (95% CI)	P-value
SPPB Score	5.7±2.7	6.5±2.7	0.007	5.8±0.2	6.4±0.2	−0.6 (−1.2, −0.1)	0.024
Balance Score	2.5±2.4	2.7±2.5	0.29	2.5±0.1	2.7±0.1	−0.2 (−0.4, 0.1)	0.24
4-meter Walk Score	2.1±1.1	2.5±1.0	0.001	2.2±0.1	2.4±0.1	−0.3 (−0.5, 0.0)	0.016
Chair Rise Score	1.0±1.1	2.3±1.2	0.035	1.0±0.1	1.3±0.1	−0.2 (−0.5, 0.0)	0.10
6 Minute Walk Distance (m)	174±103	214±105	<0.001	179±7	209±8	−30 (−52, −8)	0.007
Gait Speed (m/s)	0.57±0.22	0.64±0.22	0.002	0.58±0.02	0.63±0.02	−0.05 (−0.10, −0.01)	0.026
Modified Fried Frailty Criteria*	2.5±1.1	2.2±1.0	0.009	2.4±0.1	2.2±0.1	0.2 (0.0, 0.5)	0.05
KCCQ Overall	37±20	45±21	<0.001	38±2	45±2	−7 (−12, −3)	0.002
KCCQ Clinical	37±21	45±21	<0.001	37±2	45±2	−8 (−12, −3)	0.001
EuroQol Visual Analogue Scale	56±21	61±23	0.037	56±2	61±2	−4 (−9, 0)	0.07
Cognition (MoCA Score)	22.1±4.1	21.6±4.7	0.27	22.1±0.3	21.6±0.3	0.5 (−0.4, 1.4)	0.27
Depression (GDS-15 Score)	5.3±3.5	4.0±3.0	<0.001	5.3±0.2	4.0±0.3	1.3 (0.5, 2.0)	<0.001

Unadjusted values shown as mean±SD or frequency (%). Adjusted values shown as LSmean±SE adjusted for sex, race, and BMI and total number of comorbidities. KCCQ scores range 0–100, with higher score meaning better health status. MoCA score ranges 0–30 with higher score meaning better cognitive function. GDS-15 score ranges 0–15 with higher score meaning worse depressive symptoms.

Abbreviations: KCCQ: Kansas City Cardiomyopathy Questionnaire; PCS: physical composite score; MCS: mental composite score; MoCA: Montreal Cognitive Assessment.

^*Adjusted for sex, race, and BMI only.