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. Author manuscript; available in PMC: 2022 Feb 4.
Published in final edited form as: Oncogene. 2021 Aug 4;40(39):5788–5798. doi: 10.1038/s41388-021-01982-4

Figure 1. Cooperation between PRC2 and other proteins regulates gene transcription.

Figure 1.

(A) EED binds H3K27me3 and recruits the PRC2 complex. (B) SUZ12 regulates the activity and stability of the PRC2 complex. (C) EPOP inhibits excessive activity and chromatin binding of the PRC2.1 complex. (D) JARID2 binds H2AK119ub1 and recruits the PRC2.2 complex. (E) The interplay between PRC2 and different E3 ligases. (F) Different DNA-binding proteins regulate PRC2 actions.